Chlorodehydromethylandrostenediol (Halodrol)

[pinz]

Halodrol
Chlorodehydromethylandrostenediol


Androgenic: No data available
Anabolic: No data available
Estrogenic Activity: None
Progestational Activity: No data available
Chemical Name: 4-chloro-17a-methylandrosta-1,4-dien-3,17-diol



Description:
Chlorodehydromethylandrostenediol (CDMA) is an oral anabolic steroid derived from testosterone. It is extremely close in structure to chlorodehydromethyltestosterone (oral turinabol), differing only by the substitution of the basic steroid 3-keto group with a 3-hydroxyl. It is essentially a “diol” form of oral turinabol, and with this understanding is often described as a “prohormone” or “pro steroid” to this well known and highly valued anabolic steroid. While some conversion to active chlorodehydromethyltestosterone is assumed, based on its structure it is likely that this conversion is far from complete, and that much of the anabolic and androgenic activity received with use is intrinsic to CDMA. This steroid is non-aromatizable, and exhibits a greater tendency for anabolic as compared to androgenic effect.


How is it Supplied?
Chlorodehydromethylandrostenediol is not available as a prescription drug product. When manufactured as a supplement, it contained 50mg of steroid per tablet.


Structural Characteristics:
Chlorodehydromethylandrostenediol is a modified form of testosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, 2) the introduction of a double bond between carbons 1 and 2 (1-ene), which shifts the anabolic to androgenic ratio in favor of the former, 3) the attachment of the chloro group at carbon 4, which inhibit steroid aromatization and reduces relative androgenicity and 4) the substitution of 3-keto with 3-hydroxyl, which reduces relative steroid activity.


Side Effects (Estrogenic):
Chlorodehydromethylandrostenediol is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.


Side Effects (Androgenic):
Although chlorodehydromethylandrostenediol is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. For those with a genetic predisposition, anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, body and facial hair growth, and clitoral enlargement. Note that chlorodehydromethylandrostenediol is not extensively metabolized by the 5-alpha reductase enzyme, so its relative androgenicity is not greatly altered by the concurrent use of finasteride or dutasteride.


Side Effects (Hepatoxicity):
Chlorodehydromethylandrostenediol is a 17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of C17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain.


Side Effects (Cardiovascular):
Anablic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HFL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration, type of steroid, and level of resistance to hepatic metabolism. Chlorodehydromethylandrostenediol has a strong effect on the hepatic management of cholesterol due to its non-aromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.


Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone-stimulating substance, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.


Administration (General):
Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with indigested dietary fat, reducing absorption from the gastrointestinal tract. For maximum utilization, this steroid should be taken on an empty stomach.


Administration (Men):
Chlorodehydromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. When used for physique pr performance enhancing purposes, an effective oral daily dosage falls in the range of 50-100mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatoxicity. This level is sufficient for noticeable increases in lean muscle mass and strength. Higher doses will impart a stronger effect, but are also more likely to present significant hepatotoxicity.


Administration (Women):
Chlorodehydromethylandrostenediol was never approved for use in humans. Prescribing guidelines are unavailable. Chlorodehydromethylandrostenediol is generally not recommended for women for physique or performance enhancing purposes due to its high per-tablet dosage and the possibility of virilizing side effects. Low doses (12.5mg per day or less) are unlikely to produce virilizing side effects, provided it was used for brief periods of 4-6 weeks. Note that as with all anabolic/androgenic steroids, the chance for virilization cannot be completely excluded.


Availability:
Halodrol is no longer available, although old lots may still circulate on the black market. Several generics or spin-off brands may also still be in circulation.




**Please Note: Gaspari voluntarily discontinued production of this product (sold as a dietary supplement) in mid 2006**

[Excerpt taken from: W. Llewellyn - Anabolics 2009]